Spatial clustering of childhood leukaemia : summary results from the EUROCLUS project
Identifieur interne : 00CA93 ( Main/Exploration ); précédent : 00CA92; suivant : 00CA94Spatial clustering of childhood leukaemia : summary results from the EUROCLUS project
Auteurs : F. E. Alexander [Royaume-Uni] ; P. Boyle [Italie] ; P.-M. Carli [France] ; J. W. Coebergh [Pays-Bas] ; G. J. Draper [Royaume-Uni] ; A. Ekbom [Suède] ; F. Levi [Suisse] ; P. A. Mckinney [Royaume-Uni] ; W. Mcwhirter [Australie] ; J. Michaelis [Allemagne] ; R. Peris-Bonet [Espagne] ; E. Petridou [Grèce] ; V. Pompe-Kirn [Slovénie] ; I. Plisko [Slovaquie] ; E. Pukkala [Finlande] ; M. Rahu [Estonie] ; H. Storm [Danemark] ; B. Terracini [Italie] ; L. Vatten [Norvège] ; N. Wray [Royaume-Uni]Source :
- British journal of cancer [ 0007-0920 ] ; 1998.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Répartition géographique, Méthode statistique, Enfant.
English descriptors
- KwdEn :
Abstract
The interpretation of reports of clusters of childhood leukaemia is difficult, first because little is known about the causes of the disease, and second because there is insufficient information on whether cases show a generalized tendency to cluster geographically. The EUROCLUS project is a European collaborative study whose primary objective is to determine whether the residence locations of cases at diagnosis show a general tendency towards spatial clustering. The second objective is to interpret any patterns observed and, in particular, to see if clustering can be explained in terms of either infectious agents or environmental hazards as aetiological agents. The spatial distribution of 13 351 cases of childhood leukaemia diagnosed in 17 countries between 1980 and 1989 has been analysed using the Potthoff-Whittinghill method. The overall results show statistically significant evidence of clustering of total childhood leukaemia within small census areas (P= 0.03) but the magnitude of the clustering is small (extra-Poisson component of variance (%) = 1.7 with 90% confidence interval 0.2-3.1). The clustering is most marked in areas that have intermediate population density (150-499 persons km-2). It cannot be attributed to any specific age group at diagnosis or cell type and involves spatial aggregation of cases of different ages and cell types. The results indicate that intense clusters are a rare phenomenon that merit careful investigation, although aetiological insights are more likely to come from investigation of large numbers of cases. We present a method for detecting clustering that is simple and readily available to cancer registries and similar groups.
Affiliations:
- Allemagne, Australie, Danemark, Espagne, Estonie, Finlande, France, Grèce, Italie, Norvège, Pays-Bas, Royaume-Uni, Slovaquie, Slovénie, Suisse, Suède
- Angleterre, Canton de Vaud, Communauté valencienne, Hollande-Méridionale, Hovedstaden, Lombardie, Oxfordshire, Piémont, Trøndelag, Écosse
- Copenhague, Lausanne, Milan, Oxford, Rotterdam, Trondheim, Turin, Édimbourg
- Université d'Oxford, Université d'Édimbourg
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Le document en format XML
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Ekbom</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Uppsala Universitet, Cancer Epidemiology Unit, University Hospital</s1><s2>751 85 Uppsala</s2><s3>SWE</s3><sZ>6 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>751 85 Uppsala</wicri:noRegion></affiliation></author><author><name sortKey="Levi, F" sort="Levi, F" uniqKey="Levi F" first="F." last="Levi">F. Levi</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Institut Universitaire de Médecine Sociale et Préventive, Régistres Vaudois et Neuchâtelois des Tumeurs, CHUV-Falaises 1, 1011</s1><s2>Lausanne</s2><s3>CHE</s3><sZ>7 aut.</sZ></inist:fA14><country>Suisse</country><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Mckinney, P A" sort="Mckinney, P A" uniqKey="Mckinney P" first="P. A." last="Mckinney">P. A. Mckinney</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Information and Statistics Division of the NHS in Scotland, Trinity Park House</s1><s2>Edinburgh, EH5 3SQ</s2><s3>GBR</s3><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Edinburgh, EH5 3SQ</wicri:noRegion></affiliation></author><author><name sortKey="Mcwhirter, W" sort="Mcwhirter, W" uniqKey="Mcwhirter W" first="W." last="Mcwhirter">W. Mcwhirter</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Child Health, The University of Queensland, Royal Children's Hospital, Herston</s1><s2>Queensland 4029</s2><s3>AUS</s3><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland 4029</wicri:noRegion></affiliation></author><author><name sortKey="Michaelis, J" sort="Michaelis, J" uniqKey="Michaelis J" first="J." last="Michaelis">J. Michaelis</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Johannes Gutenberg-Universitat Mainz Klinikum, Institut fur Med Statistik und Dokumentation, Langenbeckstr. 1, Postfach 3960</s1><s2>55101 Mainz</s2><s3>DEU</s3><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>55101 Mainz</wicri:noRegion><wicri:noRegion>Postfach 3960</wicri:noRegion><wicri:noRegion>55101 Mainz</wicri:noRegion></affiliation></author><author><name sortKey="Peris Bonet, R" sort="Peris Bonet, R" uniqKey="Peris Bonet R" first="R." last="Peris-Bonet">R. Peris-Bonet</name><affiliation wicri:level="2"><inist:fA14 i1="12"><s1>Instituto de Estudios Documentales e Historicos sobre la Ciencia (IEDHC) (Universided de Valencia - CSIC), Av. Blasco Ibanez, 15</s1><s2>46010 Valencia</s2><s3>ESP</s3><sZ>11 aut.</sZ></inist:fA14><country>Espagne</country><placeName><region nuts="2" type="communauté">Communauté valencienne</region></placeName></affiliation></author><author><name sortKey="Petridou, E" sort="Petridou, E" uniqKey="Petridou E" first="E." last="Petridou">E. Petridou</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Hygiene & Epidemiology, University of Athens, School of Medicine</s1><s2>11527 Athens (GUDI)</s2><s3>GRC</s3><sZ>12 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>11527 Athens (GUDI)</wicri:noRegion></affiliation></author><author><name sortKey="Pompe Kirn, V" sort="Pompe Kirn, V" uniqKey="Pompe Kirn V" first="V." last="Pompe-Kirn">V. Pompe-Kirn</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Register Raka za Slovenijo (Cancer Registry of Slovenia), Inst. of Oncology, Zaloska 2</s1><s2>1000 Ljubljana</s2><s3>SVN</s3><sZ>13 aut.</sZ></inist:fA14><country>Slovénie</country><wicri:noRegion>1000 Ljubljana</wicri:noRegion></affiliation></author><author><name sortKey="Plisko, I" sort="Plisko, I" uniqKey="Plisko I" first="I." last="Plisko">I. Plisko</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>National Cancer Registry, Klenová 1</s1><s2>83310 Bratislava</s2><s3>SVK</s3><sZ>14 aut.</sZ></inist:fA14><country>Slovaquie</country><wicri:noRegion>83310 Bratislava</wicri:noRegion></affiliation></author><author><name sortKey="Pukkala, E" sort="Pukkala, E" uniqKey="Pukkala E" first="E." last="Pukkala">E. Pukkala</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Finnish Cancer Registry, Liisankatu 21B</s1><s2>00170 Helsinki</s2><s3>FIN</s3><sZ>15 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>00170 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Rahu, M" sort="Rahu, M" uniqKey="Rahu M" first="M." last="Rahu">M. Rahu</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Department of Epidemiology and Biostatistics, Institute of Experimental and Clinical Medicine, Hiiu 42</s1><s2>0016 Tallinn</s2><s3>EST</s3><sZ>16 aut.</sZ></inist:fA14><country>Estonie</country><wicri:noRegion>0016 Tallinn</wicri:noRegion></affiliation></author><author><name sortKey="Storm, H" sort="Storm, H" uniqKey="Storm H" first="H." last="Storm">H. Storm</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Danish Cancer Registry, Division for Cancer Epidemiology, Strandboulevarden 49, Box 839</s1><s2>2100 Copenhagen</s2><s3>DNK</s3><sZ>17 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Terracini, B" sort="Terracini, B" uniqKey="Terracini B" first="B." last="Terracini">B. Terracini</name><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Department of Biological Sciences & Human Oncology, University of Turin, Via Santena 7</s1><s2>10126 Turin</s2><s3>ITA</s3><sZ>18 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Vatten, L" sort="Vatten, L" uniqKey="Vatten L" first="L." last="Vatten">L. Vatten</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Institute of Community Medicine, University Medical Centre</s1><s2>7005 Trondheim</s2><s3>NOR</s3><sZ>19 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Wray, N" sort="Wray, N" uniqKey="Wray N" first="N." last="Wray">N. Wray</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Public Health Sciences, The University of Edinburgh, Medical School, Teviot Place</s1><s2>Edinburgh, EH8 9AG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Edinburgh, EH8 9AG</wicri:noRegion><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">98-0175294</idno><date when="1998">1998</date><idno type="stanalyst">PASCAL 98-0175294 INIST</idno><idno type="RBID">Pascal:98-0175294</idno><idno type="wicri:Area/PascalFrancis/Corpus">006770</idno><idno type="wicri:Area/PascalFrancis/Curation">006892</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">006261</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">006261</idno><idno type="wicri:doubleKey">0007-0920:1998:Alexander F:spatial:clustering:of</idno><idno type="wicri:Area/Main/Merge">00DB48</idno><idno type="wicri:Area/Main/Curation">00CA93</idno><idno type="wicri:Area/Main/Exploration">00CA93</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Spatial clustering of childhood leukaemia : summary results from the EUROCLUS project</title><author><name sortKey="Alexander, F E" sort="Alexander, F E" uniqKey="Alexander F" first="F. E." last="Alexander">F. E. Alexander</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Public Health Sciences, The University of Edinburgh, Medical School, Teviot Place</s1><s2>Edinburgh, EH8 9AG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Edinburgh, EH8 9AG</wicri:noRegion><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Boyle, P" sort="Boyle, P" uniqKey="Boyle P" first="P." last="Boyle">P. Boyle</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Epidemiology & Biostatistics, Via Ripamonti 435</s1><s2>20141 Milan</s2><s3>ITA</s3><sZ>2 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Carli, P M" sort="Carli, P M" uniqKey="Carli P" first="P.-M." last="Carli">P.-M. Carli</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Régistre des Hémopathies Malignes de la Côte d'Or, Laboratoire d'Hématologie, Hospital du Bocage, 2 Boulevard Maréchal de Lattre de Tassigny</s1><s2>21034 Dijon</s2><s3>FRA</s3><sZ>3 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>21034 Dijon</wicri:noRegion><wicri:noRegion>2 Boulevard Maréchal de Lattre de Tassigny</wicri:noRegion><wicri:noRegion>21034 Dijon</wicri:noRegion></affiliation></author><author><name sortKey="Coebergh, J W" sort="Coebergh, J W" uniqKey="Coebergh J" first="J. W." last="Coebergh">J. W. Coebergh</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Epidemiology and Biostatistics, Erasmus University</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>4 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Dutch Childhood Leukaemia Study Group (DCLSG), PO Box 43515</s1><s2>2504 AM, The Hague</s2><s3>NLD</s3><sZ>4 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>2504 AM, The Hague</wicri:noRegion></affiliation></author><author><name sortKey="Draper, G J" sort="Draper, G J" uniqKey="Draper G" first="G. J." last="Draper">G. J. Draper</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Childhood Cancer Research Group, University of Oxford, Department of Paediatrics, 57 Woodstock Road</s1><s2>Oxford, OX2 6HJ</s2><s3>GBR</s3><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Oxford, OX2 6HJ</wicri:noRegion><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Ekbom, A" sort="Ekbom, A" uniqKey="Ekbom A" first="A." last="Ekbom">A. Ekbom</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Uppsala Universitet, Cancer Epidemiology Unit, University Hospital</s1><s2>751 85 Uppsala</s2><s3>SWE</s3><sZ>6 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>751 85 Uppsala</wicri:noRegion></affiliation></author><author><name sortKey="Levi, F" sort="Levi, F" uniqKey="Levi F" first="F." last="Levi">F. Levi</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Institut Universitaire de Médecine Sociale et Préventive, Régistres Vaudois et Neuchâtelois des Tumeurs, CHUV-Falaises 1, 1011</s1><s2>Lausanne</s2><s3>CHE</s3><sZ>7 aut.</sZ></inist:fA14><country>Suisse</country><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Mckinney, P A" sort="Mckinney, P A" uniqKey="Mckinney P" first="P. A." last="Mckinney">P. A. Mckinney</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Information and Statistics Division of the NHS in Scotland, Trinity Park House</s1><s2>Edinburgh, EH5 3SQ</s2><s3>GBR</s3><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Edinburgh, EH5 3SQ</wicri:noRegion></affiliation></author><author><name sortKey="Mcwhirter, W" sort="Mcwhirter, W" uniqKey="Mcwhirter W" first="W." last="Mcwhirter">W. Mcwhirter</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Child Health, The University of Queensland, Royal Children's Hospital, Herston</s1><s2>Queensland 4029</s2><s3>AUS</s3><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland 4029</wicri:noRegion></affiliation></author><author><name sortKey="Michaelis, J" sort="Michaelis, J" uniqKey="Michaelis J" first="J." last="Michaelis">J. Michaelis</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Johannes Gutenberg-Universitat Mainz Klinikum, Institut fur Med Statistik und Dokumentation, Langenbeckstr. 1, Postfach 3960</s1><s2>55101 Mainz</s2><s3>DEU</s3><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>55101 Mainz</wicri:noRegion><wicri:noRegion>Postfach 3960</wicri:noRegion><wicri:noRegion>55101 Mainz</wicri:noRegion></affiliation></author><author><name sortKey="Peris Bonet, R" sort="Peris Bonet, R" uniqKey="Peris Bonet R" first="R." last="Peris-Bonet">R. Peris-Bonet</name><affiliation wicri:level="2"><inist:fA14 i1="12"><s1>Instituto de Estudios Documentales e Historicos sobre la Ciencia (IEDHC) (Universided de Valencia - CSIC), Av. Blasco Ibanez, 15</s1><s2>46010 Valencia</s2><s3>ESP</s3><sZ>11 aut.</sZ></inist:fA14><country>Espagne</country><placeName><region nuts="2" type="communauté">Communauté valencienne</region></placeName></affiliation></author><author><name sortKey="Petridou, E" sort="Petridou, E" uniqKey="Petridou E" first="E." last="Petridou">E. Petridou</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Hygiene & Epidemiology, University of Athens, School of Medicine</s1><s2>11527 Athens (GUDI)</s2><s3>GRC</s3><sZ>12 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>11527 Athens (GUDI)</wicri:noRegion></affiliation></author><author><name sortKey="Pompe Kirn, V" sort="Pompe Kirn, V" uniqKey="Pompe Kirn V" first="V." last="Pompe-Kirn">V. Pompe-Kirn</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Register Raka za Slovenijo (Cancer Registry of Slovenia), Inst. of Oncology, Zaloska 2</s1><s2>1000 Ljubljana</s2><s3>SVN</s3><sZ>13 aut.</sZ></inist:fA14><country>Slovénie</country><wicri:noRegion>1000 Ljubljana</wicri:noRegion></affiliation></author><author><name sortKey="Plisko, I" sort="Plisko, I" uniqKey="Plisko I" first="I." last="Plisko">I. Plisko</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>National Cancer Registry, Klenová 1</s1><s2>83310 Bratislava</s2><s3>SVK</s3><sZ>14 aut.</sZ></inist:fA14><country>Slovaquie</country><wicri:noRegion>83310 Bratislava</wicri:noRegion></affiliation></author><author><name sortKey="Pukkala, E" sort="Pukkala, E" uniqKey="Pukkala E" first="E." last="Pukkala">E. Pukkala</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Finnish Cancer Registry, Liisankatu 21B</s1><s2>00170 Helsinki</s2><s3>FIN</s3><sZ>15 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>00170 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Rahu, M" sort="Rahu, M" uniqKey="Rahu M" first="M." last="Rahu">M. Rahu</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Department of Epidemiology and Biostatistics, Institute of Experimental and Clinical Medicine, Hiiu 42</s1><s2>0016 Tallinn</s2><s3>EST</s3><sZ>16 aut.</sZ></inist:fA14><country>Estonie</country><wicri:noRegion>0016 Tallinn</wicri:noRegion></affiliation></author><author><name sortKey="Storm, H" sort="Storm, H" uniqKey="Storm H" first="H." last="Storm">H. Storm</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Danish Cancer Registry, Division for Cancer Epidemiology, Strandboulevarden 49, Box 839</s1><s2>2100 Copenhagen</s2><s3>DNK</s3><sZ>17 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Terracini, B" sort="Terracini, B" uniqKey="Terracini B" first="B." last="Terracini">B. Terracini</name><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Department of Biological Sciences & Human Oncology, University of Turin, Via Santena 7</s1><s2>10126 Turin</s2><s3>ITA</s3><sZ>18 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Vatten, L" sort="Vatten, L" uniqKey="Vatten L" first="L." last="Vatten">L. Vatten</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Institute of Community Medicine, University Medical Centre</s1><s2>7005 Trondheim</s2><s3>NOR</s3><sZ>19 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Wray, N" sort="Wray, N" uniqKey="Wray N" first="N." last="Wray">N. Wray</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Public Health Sciences, The University of Edinburgh, Medical School, Teviot Place</s1><s2>Edinburgh, EH8 9AG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Edinburgh, EH8 9AG</wicri:noRegion><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author></analytic><series><title level="j" type="main">British journal of cancer</title><title level="j" type="abbreviated">Br. J. cancer</title><idno type="ISSN">0007-0920</idno><imprint><date when="1998">1998</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">British journal of cancer</title><title level="j" type="abbreviated">Br. J. cancer</title><idno type="ISSN">0007-0920</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Child</term><term>Epidemiology</term><term>Etiology</term><term>Geographic distribution</term><term>Infection</term><term>Leukemia</term><term>Register</term><term>Spatial distribution</term><term>Statistical method</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Leucémie</term><term>Répartition spatiale</term><term>Répartition géographique</term><term>Méthode statistique</term><term>Etiologie</term><term>Infection</term><term>Registre</term><term>Epidémiologie</term><term>Enfant</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Répartition géographique</term><term>Méthode statistique</term><term>Enfant</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The interpretation of reports of clusters of childhood leukaemia is difficult, first because little is known about the causes of the disease, and second because there is insufficient information on whether cases show a generalized tendency to cluster geographically. The EUROCLUS project is a European collaborative study whose primary objective is to determine whether the residence locations of cases at diagnosis show a general tendency towards spatial clustering. The second objective is to interpret any patterns observed and, in particular, to see if clustering can be explained in terms of either infectious agents or environmental hazards as aetiological agents. The spatial distribution of 13 351 cases of childhood leukaemia diagnosed in 17 countries between 1980 and 1989 has been analysed using the Potthoff-Whittinghill method. The overall results show statistically significant evidence of clustering of total childhood leukaemia within small census areas (P= 0.03) but the magnitude of the clustering is small (extra-Poisson component of variance (%) = 1.7 with 90% confidence interval 0.2-3.1). The clustering is most marked in areas that have intermediate population density (150-499 persons km<sup>-2</sup>). It cannot be attributed to any specific age group at diagnosis or cell type and involves spatial aggregation of cases of different ages and cell types. The results indicate that intense clusters are a rare phenomenon that merit careful investigation, although aetiological insights are more likely to come from investigation of large numbers of cases. We present a method for detecting clustering that is simple and readily available to cancer registries and similar groups.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Danemark</li><li>Espagne</li><li>Estonie</li><li>Finlande</li><li>France</li><li>Grèce</li><li>Italie</li><li>Norvège</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Slovaquie</li><li>Slovénie</li><li>Suisse</li><li>Suède</li></country><region><li>Angleterre</li><li>Canton de Vaud</li><li>Communauté valencienne</li><li>Hollande-Méridionale</li><li>Hovedstaden</li><li>Lombardie</li><li>Oxfordshire</li><li>Piémont</li><li>Trøndelag</li><li>Écosse</li></region><settlement><li>Copenhague</li><li>Lausanne</li><li>Milan</li><li>Oxford</li><li>Rotterdam</li><li>Trondheim</li><li>Turin</li><li>Édimbourg</li></settlement><orgName><li>Université d'Oxford</li><li>Université d'Édimbourg</li></orgName></list><tree><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Alexander, F E" sort="Alexander, F E" uniqKey="Alexander F" first="F. E." last="Alexander">F. E. Alexander</name></region><name sortKey="Draper, G J" sort="Draper, G J" uniqKey="Draper G" first="G. J." last="Draper">G. J. Draper</name><name sortKey="Mckinney, P A" sort="Mckinney, P A" uniqKey="Mckinney P" first="P. A." last="Mckinney">P. A. Mckinney</name><name sortKey="Wray, N" sort="Wray, N" uniqKey="Wray N" first="N." last="Wray">N. Wray</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Boyle, P" sort="Boyle, P" uniqKey="Boyle P" first="P." last="Boyle">P. Boyle</name></region><name sortKey="Terracini, B" sort="Terracini, B" uniqKey="Terracini B" first="B." last="Terracini">B. Terracini</name></country><country name="France"><noRegion><name sortKey="Carli, P M" sort="Carli, P M" uniqKey="Carli P" first="P.-M." last="Carli">P.-M. Carli</name></noRegion></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Coebergh, J W" sort="Coebergh, J W" uniqKey="Coebergh J" first="J. W." last="Coebergh">J. W. Coebergh</name></region><name sortKey="Coebergh, J W" sort="Coebergh, J W" uniqKey="Coebergh J" first="J. W." last="Coebergh">J. W. Coebergh</name></country><country name="Suède"><noRegion><name sortKey="Ekbom, A" sort="Ekbom, A" uniqKey="Ekbom A" first="A." last="Ekbom">A. Ekbom</name></noRegion></country><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Levi, F" sort="Levi, F" uniqKey="Levi F" first="F." last="Levi">F. Levi</name></region></country><country name="Australie"><noRegion><name sortKey="Mcwhirter, W" sort="Mcwhirter, W" uniqKey="Mcwhirter W" first="W." last="Mcwhirter">W. Mcwhirter</name></noRegion></country><country name="Allemagne"><noRegion><name sortKey="Michaelis, J" sort="Michaelis, J" uniqKey="Michaelis J" first="J." last="Michaelis">J. Michaelis</name></noRegion></country><country name="Espagne"><region name="Communauté valencienne"><name sortKey="Peris Bonet, R" sort="Peris Bonet, R" uniqKey="Peris Bonet R" first="R." last="Peris-Bonet">R. Peris-Bonet</name></region></country><country name="Grèce"><noRegion><name sortKey="Petridou, E" sort="Petridou, E" uniqKey="Petridou E" first="E." last="Petridou">E. Petridou</name></noRegion></country><country name="Slovénie"><noRegion><name sortKey="Pompe Kirn, V" sort="Pompe Kirn, V" uniqKey="Pompe Kirn V" first="V." last="Pompe-Kirn">V. Pompe-Kirn</name></noRegion></country><country name="Slovaquie"><noRegion><name sortKey="Plisko, I" sort="Plisko, I" uniqKey="Plisko I" first="I." last="Plisko">I. Plisko</name></noRegion></country><country name="Finlande"><noRegion><name sortKey="Pukkala, E" sort="Pukkala, E" uniqKey="Pukkala E" first="E." last="Pukkala">E. Pukkala</name></noRegion></country><country name="Estonie"><noRegion><name sortKey="Rahu, M" sort="Rahu, M" uniqKey="Rahu M" first="M." last="Rahu">M. Rahu</name></noRegion></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Storm, H" sort="Storm, H" uniqKey="Storm H" first="H." last="Storm">H. Storm</name></region></country><country name="Norvège"><region name="Trøndelag"><name sortKey="Vatten, L" sort="Vatten, L" uniqKey="Vatten L" first="L." last="Vatten">L. Vatten</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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